Factors predisposing to the development of progressive massive fibrosis in coal miners.
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چکیده
منابع مشابه
Factors predisposing to the development of progressive massive fibrosis in coal miners.
Altogether 238 759 miners employed by the National Coal Board were examined in the third of the Board's radiological surveys from 1969 to 1973 inclusive. Excluding those diagnosed as having progressive massive fibrosis (PMF) on that occasion, 210 847 were in collieries still operating at the time of the fourth survey four to five years later 132 728 attended for radiography at the same colliery...
متن کاملGenetic susceptibility to progressive massive fibrosis in coal miners.
Progressive massive fibrosis (PMF) is a chronic interstitial lung disease with a complex aetiology that can occur after cumulative dust exposure. A case-control study was conducted to test the hypothesis that single nucleotide polymorphisms (SNPs) within genes involved in inflammatory and fibrotic processes modulate the risk of PMF development. The study population consisted of 648 underground ...
متن کاملLack of association between antioxidant gene polymorphisms and progressive massive fibrosis in coal miners.
BACKGROUND Oxidative stress plays a major role in the pathogenesis of interstitial lung diseases. The antioxidant enzymes glutathione S-transferases (GST) and manganese superoxide dismutase (MnSOD) are important components of lung defence against oxidative stress, and polymorphisms in the genes which regulate their expression may represent important disease modifiers. METHODS A matched case-c...
متن کاملResurgence of Progressive Massive Fibrosis in Coal Miners - Eastern Kentucky, 2016.
Coal workers' pneumoconiosis, also known as "black lung disease," is an occupational lung disease caused by overexposure to respirable coal mine dust. Inhaled dust leads to inflammation and fibrosis in the lungs, and coal workers' pneumoconiosis can be a debilitating disease. The Federal Coal Mine Health and Safety Act of 1969 (Coal Act),* amended in 1977, established dust limits for U.S. coal ...
متن کاملProgressive massive fibrosis and simple pneumoconiosis in ex-miners.
A group of 17 738 working miners, medically examined during 1953-8, were followed up from 1974 to 1980. Of the 7118 men re-examined, 2547 were still working miners and 4526 had left the industry (45 were of unrecorded status). The incidence of progressive massive fibrosis (PMF) over an average follow up period of 22 years among men who had remained in the industry was 27 per 1000, but 94 per 10...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1981
ISSN: 1351-0711
DOI: 10.1136/oem.38.4.321